| abstract |
An effective and efficient detoxification that is effective in substantially neutralizing the anticoagulant activity of an fXa inhibitor and in initiating a clotting process in the event of an overdose fXa inhibitor. Provide the agent. The present invention uses a factor Xa (fXa) derivative in combination with a blood coagulant to prevent or reduce bleeding in a subject undergoing anticoagulation therapy with a factor Xa inhibitor. Regarding the method. The present invention also relates to a composition comprising the fXa derivative and the blood coagulant. Said fXa derivatives have reduced endogenous procoagulant activity or no endogenous procoagulant activity, are capable of binding and / or neutralizing fXa inhibitors, and assembled to prothrombinase Do not build a complex. The blood coagulant has a procoagulant activity, an antithrombolytic activity, and / or an antifibrinolytic activity. [Selection figure] None |