| abstract |
Disclosed is a compound having the beneficial activity of dextromethorphan used as a general antitussive and also having other benefits, such as reduced side effects, due to reduced metabolic tendency. The following novel morphinan compounds. [R1 is CH3, CH2D, CHD2, CD3, CHF2, and CF3; R2 is CH3, CH2D, CHD2, and CD3; provided that when R1 is CH3, R2 is not CH3 or CD3, and R1 is CD3 If R2 is not CH3] [Selection] Figure 1 |