| abstract |
A stitched polypeptide is provided. The present invention provides stitched polypeptides of the invention, pharmaceutical compositions thereof, and methods of making and using the stitched polypeptides of the invention. In certain embodiments, the present invention relates to novel stitched polypeptides having an α helix structure. In certain embodiments, an α-helical polypeptide of the invention maintains an α-helical structure under physiological conditions, such as within a subject's body (eg, in the gastrointestinal tract, in the bloodstream). The α-helical polypeptides of the invention have the formulas (I)-(VII) described herein. [Selection figure] None |