| abstract |
Disclosed is a medicament for treating a disease involving overproduction of amyloid-beta peptide, such as Alzheimer's disease (AD). An antisense oligonucleotide or ribozyme that inhibits gene expression of casein kinase 1 involved in the production of amyloid-beta peptide, and an aminopyrimidine-indole that inhibits kinase activity, such as matayresinol and antibodies No pharmaceutical composition containing any casein kinase 1 modulator |