| abstract |
To provide a triptolide product. The present invention provides a compound of formula (I): or a salt thereof. The present invention also provides pharmaceutical compositions comprising compounds of formula I, processes for preparing compounds of formula I, intermediates useful for preparing compounds of formula I, and methods of treatment using compounds of formula I To do. The invention also expresses HSP70 in a mammal (eg, a human) comprising administering to the mammal (eg, a human) an inhibitory amount of a compound of Formula I or a pharmaceutically acceptable salt thereof. Methods are provided for inhibiting the growth of cancer cells in a cancer (eg, pancreatic cancer, neuroblastoma, breast cancer, colon cancer, stomach cancer, liver cancer, or glioblastoma). [Selection figure] None |