| abstract |
Compositions and methods related to improving the pharmacological properties of biologically active compounds targeting the nervous system, particularly the permeability of the blood brain barrier. A galanin having the amino acid sequence of Sar-Trp-Thr-Leu-Asn-Ser-Ala-Gly-Tyr-Leu-Leu-Gly-Pro-Lys-Lys- (Lys-palm) -Lys-NH 2 Similar polypeptide. An isolated polypeptide comprising an amino acid sequence at least about 90% identical to said amino acid sequence, or an amino acid sequence having one or more conservative amino acid substitutions. In addition, compositions with high blood-brain barrier permeability include peptides that have high lipophilic properties and high basicity when compared to an unaltered form of the peptide. [Selection] Figure 1 |