| abstract |
Kind Code: A1 The present invention provides a gene of a non-typeable strain of Haemophilus influenzae (NTHi) and use thereof. The present invention relates to a polynucleotide sequence of a non-typeable strain of Haemophilus influenzae (NTHi), a polypeptide encoded by the polynucleotide, and uses thereof. The invention also relates to NTHi genes that are up-regulated during or in response to NTHi infection of the middle ear or nasopharynx. The invention also relates to the use of these NTHi polynucleotides and NTHi polypeptides, including vaccines and methods for treating and preventing NTHi-related disorders. [Selection figure] None |