| abstract |
PROBLEM TO BE SOLVED: To provide a novel compound for diagnosing a disease related to expression of vascular cell adhesion molecule-1 (VCAM), a preparation method thereof, and use thereof in medical imaging. A signal-link-peptide comprising a VCAM target peptide, wherein the VCAM target peptide includes the following peptides: a) X1-X2-X3-X4-X5-X6-X7-X8- X9, preferably a peptide called peptide NNSKSHT; or b) a compound selected from X10-X11-X12-X13-X14-X15-X16-X17-X18, preferably peptide CMKTTDTRLC, and functional equivalents thereof, And a pharmaceutically acceptable salt of compound a) or b). Furthermore, a compound in which Signal is a paramagnetic metal, a chelate that may or may not be coupled to a radionuclide, and a radionuclide for PET imaging is Ga68. [Selection figure] None |