| abstract |
Nitroxyl (HNO) is released at a controlled rate under physiological conditions, the rate of HNO release being modulated by changing the properties and position of functional groups on the N-hydroxylsulfonamide derivative. N-hydroxylsulfonamide derivatives are provided that are useful for treating and / or preventing the onset and / or progression of diseases or abnormalities that respond to nitroxyl therapy, including heart failure and ischemia / reperfusion injury. The following N-hydroxylsulfamide derivatives represented by the chemical formula [Selection figure] None |