| abstract |
There is a need for compounds containing small particles containing active nucleic acid agents for intercellular delivery as therapeutic methods and methods for making such compounds. In particular, the provision of compounds and methods for delivering double stranded RNA to cells to generate an RNAi response. A compound comprising condensed particles less than 1000 nm in diameter, wherein the particles comprise one or more double-stranded ribonucleic acids (dsKNA) and one or more peptides. This compound, composition, and production method are useful for the regulation of gene expression by RNA interference. [Selection] Figure 10 |