| abstract |
An agent that functions as a potent regulator of TGF-β signaling is provided. In one aspect, the present invention provides compositions and methods for modulating (promoting or inhibiting) the growth of tissues such as bone, cartilage, muscle, fat, and / or nerve tissue. The present invention also provides methods for screening for compounds that modulate the activity of ActRIIB protein and / or ActRIIB ligand. The compositions and methods provided in this summary are useful for the treatment of diseases associated with abnormal activity of ActRIIB protein and / or ActRIIB ligand. [Selection] Figure 1 |