abstract |
The present invention provides compositions and methods of treatment comprising oligonucleotides suitable for administration to humans and other mammals. An achiral 5 wherein a modified oligonucleotide that is complementary to a region of a gene associated with a pathological disorder is selected from the group consisting of a 5 ′ UTR region, a translation initiation site, a 3 ′ UTR, and a translation termination site. A modified oligonucleotide of about 7-75 nucleotides comprising 7 or more consecutive ribose groups joined by a 'to 3' internucleoside phosphate linkage. And a method of treatment wherein the oligonucleotide is administered orally. [Selection figure] None |