abstract |
A factor D antibody or antigen-binding fragment thereof is provided. The antibody or antigen-binding fragment thereof comprises: (i) a light chain CDR1 sequence comprising: (i) a specific amino acid residue 24-34, or a variant thereof comprising a modification of one residue; (ii) a specific A light chain CDR2 sequence, including amino acid residues 50-56, or variants thereof containing one residue modification, (iii) certain amino acid residues 89-97, or one residue modification thereof Including light chain CDR3 sequences, including variants. [Selection figure] None |