| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_10e4b1416c6e66e0ade5429212414964 |
| classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C2602-08 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-16
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-24
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C209-84
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P43-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-28
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C209-86 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C209-88
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07B57-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-135
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P43-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P25-16
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C211-42 |
| filingDate |
2013-11-11-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_fe7112e63868a4ad83e093f0ae2fc91b
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_bd4eccebd117ffdfc769bb706ee19118
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_86bf973924afcd09818832c08e87512f
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_5adbaebe51949f5fbd6b09d6159d461b |
| publicationDate |
2014-04-24-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
JP-2014074033-A |
| titleOfInvention |
Method for the separation of propargylated aminoindan |
| abstract |
The present invention provides a method for isolating a salt of mono-propargylated aminoindan (rasagiline), which is a selective blocker of MAO-B and useful for the treatment of Parkinson's disease and the like, from a reaction mixture. A method for isolating a salt of a mono-propargylated aminoindane having the following structure from a reaction mixture comprising: a) addition of an acid to the reaction mixture; b) mono-propargylated amino A process comprising crystallization of mono-propargylated aminoindane under conditions suitable for the formation of a crystalline salt of indan; and c) a recovery step of the crystalline salt of mono-propargylated aminoindane. A pharmaceutical composition comprising a crystalline diastereoisomeric salt and a salt. [Selection figure] None |
| priorityDate |
2005-11-17-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |