| abstract |
Toll-like receptor 9 agonist suppresses stimulatory effect on human peripheral blood mononuclear cell proliferation, and Toll-like receptor 9 agonist, type I herpes simplex virus, influenza virus and systemic lupus erythematosus sera are human Provided is an oligonucleotide that suppresses the stimulating action of peripheral blood mononuclear cells on interferon production and suppresses an individual from developing a cytokine-mediated lethal shock. An oligonucleotide having a nucleotide sequence of 5'-cctcctcctcctcctcctcctcct-3 ', which treats systemic lupus erythematosus, sepsis, multiple organ dysfunction syndrome and other immune-mediated diseases Can be used to [Selection figure] None |