http://rdf.ncbi.nlm.nih.gov/pubchem/patent/JP-2014065679-A
Outgoing Links
Predicate | Object |
---|---|
assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_1d29f7ac2c7f9be9f7dae1a83bbb5c92 |
classificationIPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-551 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P25-18 |
classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D495-04 |
filingDate | 2012-09-26-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_d759ee7d9b3cef593959d0fa2678310a http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_62d88549579d0ba8846097c6677a2ef7 |
publicationDate | 2014-04-17-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
publicationNumber | JP-2014065679-A |
titleOfInvention | Olanzapine production method |
abstract | PROBLEM TO BE SOLVED: To provide olanzapine useful as an antipsychotic drug with high purity. SOLUTION: 4-Amino-2-methyl-10H-thieno [2,3-b] [1,5] benzodiazepine hydrochloride and N-methylpiperazine are reacted at 80 to 120 ° C. without solvent to obtain olanzapine. In the production method, the reaction mixture obtained by the above reaction is cooled to 60 to 80 ° C., and for example, 4-amino-2-methyl-10H-thieno [2,3-b] [1 , 5] After mixing 1.18 times by weight of acetonitrile with respect to benzodiazepine hydrochloride, 4-amino-2-methyl-10H-thieno [2,3-b] [2,3-b] [ 1,5] benzodiazepine hydrochloride is added with, for example, 3 times by weight of water to precipitate olanzapine. [Selection figure] None |
priorityDate | 2012-09-26-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 29.