abstract |
Modified Factor VII polypeptides and methods of use thereof are provided. A modified FVII polypeptide, or an active fragment thereof, wherein the modified FVII polypeptide exhibits increased tissue factor (TF) dependent clotting activity as compared to an unmodified FVII polypeptide. A nucleic acid molecule comprising a sequence of nucleotides encoding the modified FVII polypeptide. A vector comprising the nucleic acid molecule. A cell containing the vector. A method for producing a modified FVII polypeptide, comprising a step of culturing the cell. A pharmaceutical composition comprising a therapeutically effective concentration or amount of the modified FVII polypeptide or the nucleic acid molecule or the vector or the cell in a pharmaceutically acceptable medium. [Selection figure] None |