http://rdf.ncbi.nlm.nih.gov/pubchem/patent/JP-2014037379-A
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_e66dcd041b390d50bd6668a9009a1e6f |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K47-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K47-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P43-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K9-19 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-222 |
| filingDate | 2012-08-16-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_88ffff5e0aed620baca1bcbb1386ab48 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_bf827f3a81a4d7b1ee3215118baf14fc |
| publicationDate | 2014-02-27-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | JP-2014037379-A |
| titleOfInvention | Pharmaceutical preparation and method for producing the same |
| abstract | PROBLEM TO BE SOLVED: To improve the stability of cibelestat, for example, to suppress the formation of related substances due to the degradation of cibelestat which can occur immediately after dissolution in a solvent for use, and to generate and inject undesired precipitates during the preparation of the preparation To provide a pharmaceutical preparation capable of preventing the generation of insoluble substances when dissolved in water or the like, and a method for producing the same. Disclosed is a pharmaceutical preparation containing a lyophilizate of a solution containing sivelestat, pyrophosphoric acid or a salt thereof, and disodium hydrogen phosphate. The pharmaceutical preparation of the present invention, for example, suppresses the production of a relative substance of cyberestat when used as an injection and exhibits excellent solubility in a solvent such as water for injection. Thus, it is useful as a preparation that improves the stability of cibelestat and is used for the improvement of acute acceptance associated with systemic inflammatory response syndrome. [Selection figure] None |
| isCitedBy | http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-115144513-A |
| priorityDate | 2012-08-16-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 45.