| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_9a6117d8ae0e22ed58066d865f8bfd61 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D209-90
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D207-46 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-403
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D209-44
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P3-10 |
| filingDate |
2013-07-26-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_223a175b01bc18b9559f20f9f820f8ef
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_bb0a3f673e7c4188325282f1d28ef8ec
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_9bbeadf2a6ce0cebca7c8fa8c9ed9f17 |
| publicationDate |
2014-02-20-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
JP-2014031372-A |
| titleOfInvention |
An efficient method for preparing high purity mitiglinide |
| abstract |
The present invention provides an efficient method for preparing high purity mitiglinide. A) converting (S) -2-benzylsuccinic acid XII to the corresponding acid chloride; b) esterifying XV to diester XVI using N-hydroxysuccinimide. c) regioselective reaction of diester XVI with cis-hexahydroisoindoline to give monoamide monoester XVII; d) hydrolysis of the ester group of XVII to give mitiglinide (I); and Accordingly, e) preparation by a step of chlorinating mitiglinide to the corresponding calcium salt dihydrate (II). [Selection figure] None |
| priorityDate |
2012-07-31-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |