http://rdf.ncbi.nlm.nih.gov/pubchem/patent/JP-2014031349-A
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_9a177f0fa84b1b2134e13caa36974ce3 http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_dde4bd55af3d38a55adf5945039d2b45 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K7-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K7-08 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-09 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K47-48 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K47-42 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K9-127 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K14-00 |
| filingDate | 2012-08-06-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_e8ef2e7a67a3d51795240366f8617fe4 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_72f373a9c498001d61afc4f6abefe508 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_c1655581b96a05f99d369b65471ecee6 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_ce05ee6fa4141e45191a7c8b50d773b1 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_ff3d78637f2ba2a4fe8a8b07e620d3e9 |
| publicationDate | 2014-02-20-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | JP-2014031349-A |
| titleOfInvention | Binder and its use |
| abstract | When a D-MEND encapsulating a complex with a drug substance is taken into a eukaryotic cell, the drug substance is retained in the endosome, and the drug substance in the cytoplasm and / or nucleus. A binding agent capable of dissociating the complex, a complex of the binder and a pharmaceutical substance, D-MEND encapsulating the complex, a liposome preparation containing the D-MEND, and the like. Hydrophobic group-modified polyhistidine can form a complex by interacting with nucleic acid and the like, and retains nucleic acid and the like under acidic conditions, and binds nucleic acid and the like under neutral conditions. Hydrophobic group-modified polyhistidine is useful as a binder because it can be dissociated. In addition, a complex of a hydrophobic group-modified polyhistidine and a nucleic acid or the like and a D-MEND encapsulating the complex are useful for transporting the nucleic acid or the like into the cell, and a liposome containing the D-MEND encapsulating the complex The preparation is useful as a next-generation pharmaceutical. [Selection] Figure 4 |
| isCitedBy | http://rdf.ncbi.nlm.nih.gov/pubchem/patent/JP-2021043045-A http://rdf.ncbi.nlm.nih.gov/pubchem/patent/JP-7271374-B2 |
| priorityDate | 2012-08-06-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 41.