| abstract |
Disclosed is a compound which is a tissue non-specific alkaline phosphatase inhibitor. Disclosed herein is a tissue non-specific alkaline phosphatase inhibitor. The disclosed compounds are used to treat, prevent, or alleviate vascular calcification, arterial calcification, and other cardiovascular diseases. In one embodiment, a compound of the present disclosure can include: A) a ring containing two or more nitrogen atoms; B) an arylsulfonamide; and C) a tissue having an IC 50 of 20 μM or less. A compound that inhibits non-specific alkaline phosphatase, comprising one or more arylphosphonic acid units or phosphonic acid units. [Selection figure] None |