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publicationDate 2014-02-13-04:00^^<http://www.w3.org/2001/XMLSchema#date>
publicationNumber JP-2014028854-A
titleOfInvention Dosage form and method of drug administration
abstract [PROBLEMS] To provide a dosage form and method for administering a central nervous system drug in a sustained and constantly increasing rate per unit time to obtain an intended therapeutic effect and at the same time reduce the occurrence of an undesirable effect. Provided. Methylphenidate for providing a substantially increased plasma concentration of methylphenidate or a pharmaceutically acceptable salt thereof during a period between 2.5 hours after administration and 5.5 hours after administration. An oral dosage form comprising a hydrogel matrix containing a plurality of pills that releases a date or a pharmaceutically acceptable salt thereof in a sustained and increasing dosage over time, comprising (i) said substantially The above-mentioned oral preparation, wherein the increasing plasma concentration comprises an increase in plasma concentration in a continuous 1 hour increase during the period, and (ii) the peak plasma concentration is reached at or above 4 hours after administration form. [Selection figure] None
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