| abstract |
In various aspects, systems, devices, and methods relating to ex vivo organ care are provided. To evaluate 1) total perfusion status of the isolated heart, 2) metabolic status of the isolated heart, and 3) total vessel patency of the isolated donor heart, an organ care system cardiac perfusion device is used. Lactate measurements are used on arterial and venous blood lines. An aspect of the present invention is the unique ability of cardiomyocytes to produce / generate lactate when oxygen is depleted and to metabolize / utilize lactate for energy production when fully perfused with oxygen. Use certain properties. [Selection] Figure 21C |