| abstract |
The present invention provides chimeric human antibodies, recombinant antibodies, synthetic antibodies, and nucleic acids encoding them, and methods for making and using these immunoglobulins. An antibody having a framework from one species and a sequence from another species that serves to bind antigen, comprising a consensus human framework region, or “independent consensus framework (ICF)” Libraries and kits comprising polypeptides consisting of, nucleic acids encoding them, and ICFs and / or antibodies thereof individually and in combinatorial libraries and combinations. [Selection figure] None |