abstract |
The present invention provides a method for producing a 3-hydroxypropan-1-one compound, a 2-propen-1-one compound, and an isoxazoline compound that are useful as production intermediates such as pharmaceuticals and agricultural chemicals. [Solution] Starting from an aromatic ketone compound represented by the formula (4) and a substituted acetophenone compound represented by the formula (5) in an organic solvent or water in the presence or absence of an additive, in the presence of a base, A method for producing a 1,3-bis (substituted phenyl) -3-substituted-3-hydroxypropan-1-one compound represented by formula (3) by carrying out the reaction in a turbid state, represented by formula (3) A method for producing a 1,3-bis (substituted phenyl) -3-substituted-2-propen-1-one compound represented by formula (2) by dehydration of the compound, and (4) and (5) A method of producing (2) in one step via (3). [Selection figure] None |