| abstract |
The present invention provides a multivalent immunogenic composition having 15 different polysaccharide-protein conjugates that is effective in preventing Streptococcus pneumoniae. Each conjugate is a different serotype of S. pneumoniae (1, 3, 4, 5, 6A, 6B, 7F, 9V, 14, 18C, 19A, conjugated to a carrier protein, preferably CRM197. 19F, 22F, 23F or 33F). The immunogenic composition is preferably formulated as a vaccine with an aluminum-based adjuvant and results in a high inoculation rate against pneumococcal disease, particularly in infants and young children. The adjuvant is aluminum phosphate. [Selection figure] None |