| abstract |
An object of the present invention is to provide a cost-effective method for producing a macrolide with a high yield and a treatment method using the macrolide. Tylosin A (or a salt thereof) is reacted with a specific piperidinyl compound and formic acid to form a 20-piperidinyl-tylosin compound, then reacted with an acid, further reacted with an acid, and 23 Forming a hydroxy-20-piperidinyl-5-O-mycaminosyl-tylonolide compound and further forming an activated compound with an activator, or reacting the activated compound again with a piperidinyl compound, or a macrolide thereof Method for producing salt. An animal in need of producing the macrolide or a pharmaceutically acceptable salt thereof and treating a disease selected from the group consisting of pasteurellosis, porcine respiratory disease and bovine respiratory disease with a therapeutically effective amount of the macrolide or salt. A method for treating the disease, comprising administering to the disease. [Selection figure] None |