| abstract |
The present invention is useful for the treatment or prevention of diseases or conditions mediated by specific mutant forms of epidermal growth factor receptor (eg, L858R activating mutant, Exon19 deletion activating mutant, and T790M resistant mutant). It relates to certain 2- (2,4,5-substituted-anilino) pyrimidine compounds and their pharmaceutically acceptable salts. Such compounds and salts thereof may be useful for the treatment or prevention of various cancers. The present invention relates to various forms of EGFR using the compounds and salts thereof, various particularly useful polymorphs of the compounds and salts, intermediates useful for the preparation of the compounds, and the compounds and salts thereof. It also relates to methods for treating intervening diseases. |