http://rdf.ncbi.nlm.nih.gov/pubchem/patent/JP-2013543853-A
Outgoing Links
Predicate | Object |
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classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K38-00 |
classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P1-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K14-605 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P15-08 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P15-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P1-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P3-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P3-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P3-08 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P3-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P43-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K47-542 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P7-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P9-00 |
classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K38-26 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P9-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P3-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P3-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P15-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K14-605 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P1-00 |
filingDate | 2011-11-09-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
publicationDate | 2013-12-09-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
publicationNumber | JP-2013543853-A |
titleOfInvention | Double acylated GLP-1 derivative |
abstract | The present invention relates to a derivative of a GLP-1 analog, or a pharmaceutically acceptable salt, amide, or ester thereof, wherein the analog corresponds to position 18 of GLP-1 (7-37) (SEQ ID NO: 1). The first K residue in, a second K residue in another position, and a maximum of 12 amino acid changes compared to GLP-1 (7-37), the derivative via a linker Each comprising two extensions attached to the first and second K residues, wherein the extensions are Chem.1, Chem.2, and Chem.3: Chem.1: HOOC- (CH 2) x -CO- *, Chem.2: HOOC-C 6 H 4 -O- (CH 2) y -CO- *, Chem.3: R 2 -C 6 H 4 - (CH 2) z -CO - * (Wherein x is an integer in the range of 6-18, y is an integer in the range of 3-17, z is an integer in the range of 1-5, R 2 is 150 Da The linker is selected from Chem. 4: * -NH- (CH 2 ) 2- (O- (CH 2 ) 2 ) k -O- (CH 2 ) n- CO- * (wherein, k is from 1 to 5 Range is an integer, n is including an a) integer ranging from 1 to 5. The invention also relates to its pharmaceutical use, for example in the treatment and / or prevention of all forms of diabetes and related diseases, and corresponding novel peptides and side chain intermediates. The derivative is suitable for oral administration. |
isCitedBy | http://rdf.ncbi.nlm.nih.gov/pubchem/patent/JP-2017514801-A |
priorityDate | 2010-11-09-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 839.