| abstract |
The present invention relates to a novel drug delivery system comprising a drug-protein-polymer triple conjugate. The triple conjugate comprises (i) a protein moiety capable of selectively binding to a specific target site possessed by a cell / affected organ, (ii) a polymer moiety covalently bound to the protein, and (iii) said polymer moiety Alternatively, an active drug moiety is used that includes one or more drugs covalently linked to either of the protein moieties. The conjugates of the invention have target specificity and good selectivity for a defined cell / organ population. The invention further relates to a method of preparing the conjugate and a method of treatment comprising administering the conjugate as a unit. The conjugates of the invention are beneficially used for therapeutic as well as non-therapeutic, eg diagnostic applications. |