http://rdf.ncbi.nlm.nih.gov/pubchem/patent/JP-2013541942-A
Outgoing Links
Predicate | Object |
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classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12R2001-19 |
classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12P17-182 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D487-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12P41-002 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N1-205 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N9-0004 |
classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D487-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12P17-18 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-09 |
filingDate | 2011-10-10-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
publicationDate | 2013-11-21-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
publicationNumber | JP-2013541942-A |
titleOfInvention | Methods for producing sitagliptin intermediates by enzymatic conversion |
abstract | The present invention relates to 3-hydroxy-1- (3- (trifluoromethyl) -5,6-dihydro- [1,2,4] triazolo [4,3-a] pyrazin-7 (8H) -yl)- Racemic form of 4- (2,4,5-trifluorophenyl) butan-1-one (Formula 1) (R / S), or its optically active form (S or R), or an enantiomer of any form A method of preparing an enantiomeric excess mixture is provided. The method comprises: a) 4-oxo-4- [3- (trifluoromethyl) -5,6-dihydro [1,2,4 of formula (III) in the presence of a suitable cofactor under suitable conditions ] Triazolo [4,3-a] pyrazin-7 (8H) -yl] -1- (2,4,5-trifluorophenyl) butan-2-one, suitable oxidoreductase, or a suitable variant thereof Reacting with; and b) 3-hydroxy-1- (3- (trifluoromethyl) -5,6-dihydro- [1,2,4] triazolo [4,3-a] pyrazin-7 (8H) -yl) -4- Racemic form of (2,4,5-trifluorophenyl) butan-1-one (R / S), or its optically active form (S or R), or any form of enantiomeric excess mixture Isolating) including. [Selection figure] None |
priorityDate | 2010-10-08-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 1002.