| abstract |
Disclosed are substances and methods for reducing or preventing metastatic behavior in VGSC-expressing cancers by eliminating at least the transient portion of the voltage-gated sodium channel current, with the effect of at least reducing the sustained portion of the current . Inhibition of metastatic cell behavior such as exfoliation, lateral motility, transverse migration and invasiveness using the known drugs ranolazine and riluzole has been demonstrated. |