| abstract |
The present invention relates to the use of benzimidazole derivatives to modulate, in particular inhibit, the activity or function of the phosphoinositide 3′OH kinase family (hereinafter PI3 kinase), suitably PI3Kα, PI3Kδ, PI3Kβ, and / or PI3Kγ. Suitably, the present invention provides an autoimmune disorder, inflammatory disease, cardiovascular disease, neurodegenerative disease, allergy, asthma, pancreatitis, multiple organ failure, kidney disease, platelet aggregation, cancer, sperm motility, transplant rejection, It relates to the use of benzimidazole in the treatment of one or more disease states selected from graft rejection and lung injury. More suitably, the present invention relates to PI3Kβ selective benzimidazole compounds for treating cancer. [Selection figure] None |