| abstract |
PEG-modified exendin-4 analogs and their uses are disclosed. In particular, the formula (I): PEG-M- X- (Ex-4) PEG -modified exendin-4 analog represented by or a pharmaceutically acceptable salt thereof, and Formula (II): [Aa p] Exendin Exendin-4 analogs indicated by -4 are disclosed (where each symbol has the meaning defined herein). Further methods of preparing PEG-modified exendin-4 analogs, the use of PEG-modified exendin-4 analogs, compositions comprising PEG-modified exendin-4 analogs, and exendin-4 in the preparation of PEG-modified exendin-4 analogs The use of analog is disclosed. In the PEG-modified exendin-4 analog, modification with polyethylene glycol occurs site-specifically in the peptide chain of exendin-4. PEG-modified exendin-4 analogs can be used for the prevention and / or treatment of diseases and / or symptoms associated with decreased activity of the GLP-1 receptor (eg, type II diabetes). [Selection figure] None |