abstract |
[Chemical 1] The present invention provides a spirocyclic amine derivative of formula (I) wherein R1; R2; R3; Q; -WT-; R5; Z; and A have the definitions provided in the claims; It relates to their pharmaceutically acceptable salts, solvates or hydrates or one or more N-oxides thereof. The compounds of the present invention have affinity for the S1P receptor and can be used in the treatment, alleviation or prevention of diseases and conditions involving the S1P receptor (s). |