| abstract |
Systemic lupus erythematosus (SLE), myasthenia gravis, rheumatoid arthritis, acute disseminated encephalomyelitis, idiopathic thrombocytopenic purpura, multiple sclerosis, Sjogren's syndrome and autoimmune hemolytic anemia, allergic conditions ( Systemic inflammation, arthritis, rheumatic diseases, osteoarthritis, inflammatory bowel disorders, inflammatory eye disorders, inflammation or unstable bladder disorders, including but not limited to autoimmune diseases, including all forms of hypersensitivity) Substituted bicyclic heteroaryls of the following formula for the treatment of psoriasis, skin diseases with inflammatory components, chronic inflammatory conditions and compositions comprising them. The present invention also provides for leukemias such as acute myeloid leukemia (AML) myelodysplastic syndrome (MDS) myeloproliferative disease (MPD) chronic myelogenous leukemia (CML) T cells acute lymphoblastic leukemia (T-ALL) B cells. Methods for treating p110 activity-mediated, dependent or related cancers include but are not limited to acute lymphoblastic leukemia (B-ALL) non-Hodgkin lymphoma (NHL) B-cell lymphoma and solid tumors (such as breast cancer) Make it possible. [Selection] No figure |