| abstract |
Electrokinetically modified fluid comprising a charge-stabilized oxygen-containing nanostructured ionic aqueous solution in an amount sufficient to treat an inflammatory neurodegenerative condition or disease or at least one symptom thereof (eg, Electrokinetically modified gas-enriched fluids and solutions) are provided. Electrokinetically modified fluids or therapeutic compositions and methods include electrokinetically modified ionic aqueous fluids, optionally in combination with other therapeutic agents. Certain embodiments provide for modulation of tau protein phosphorylation and / or aggregation. Particular embodiments are described above by modulating at least one of cell membrane potential and / or cell membrane conductivity, membrane receptors, such as, but not limited to, G protein-coupled receptors, and membrane proteins such as intercellular binding. Provides modulation or regulation of intracellular signaling associated with inflammatory responses. Other embodiments include specific administration routes or formulations for electrokinetically modified fluids and therapeutic compositions. [Selection] Figure 18B |