| abstract |
The present invention relates to a method for removing, reducing or preventing bacterial biofilms using a fusion protein comprising endolysin, autolysin or bacteriocin fused with a peptide having membrane disrupting activity or LPS disrupting activity. Furthermore, the present invention is for use as a medicament, in particular as a medicament, diagnostic means, disinfectant or cosmetic substance for the treatment or prevention of gram-negative and / or gram-positive bacterial infections associated with bacterial biofilms. Relating to the fusion protein. The present invention also includes gram-negative and / or gram-positive bacteria contamination associated with bacterial biofilms on food, food processing equipment, food processing factories, food contact surfaces, medical devices, hospital surfaces and operating room surfaces. Also related to the removal or reduction or prevention. Furthermore, the present invention relates to the use of said fusion protein as a diagnostic tool in a pharmaceutical, food or feed or environmental diagnostic method associated with a bacterial biofilm. [Selection] Figure 1 |