| abstract |
Provided is an isolated protein complex comprising keratinocyte growth factor and vitronectin, or at least those domains capable of binding and activating both keratinocyte growth factor receptor and integrin receptor for vitronectin . These protein complexes include synthetic proteins in which a keratinocyte growth factor sequence and a vitronectin sequence are joined by a linker sequence. In certain forms, the vitronectin sequence does not include a C-terminal heparin binding domain. Also, for stimulating or inducing cell migration and / or proliferation in cosmetic and therapeutic treatments such as wound healing, tissue engineering, skin replacement and skin replacement where epithelial cell migration is required, and in the treatment of burns, The use of these protein complexes is also provided. In other embodiments, the present invention provides suppression of cancer cell metastasis, particularly in the context of breast cancer. |