| abstract |
A composition intended for use for therapeutic purposes comprises nicotine and at least one other nicotinic compound. Representative forms of nicotine are as free base (eg as a mixture of nicotine and microcrystalline cellulose), as nicotine salt form (eg as nicotine ditartrate) or as nicotine polacrilex It may be. Other nicotinic compounds are compounds that can be considered to selectively bind to specific nicotinic receptor subtypes, and in particular to the nicotinic receptor subtype of the central nervous system. For example, the other nicotinic compound may be a compound that selectively binds to the nicotinic receptor subtype α7 or α4β2. The compositions are useful for treating CNS conditions, diseases and disorders, and as nicotine replacement therapy. |