| abstract |
The present invention includes a method for promoting the uptake of an antigen into a cell by an antigen-binding molecule, a method for promoting a decrease in the antigen concentration in plasma, a method for increasing the number of antigens that can be bound by one antigen-binding molecule, Methods for improving the pharmacokinetics of antigen-binding molecules, antigen-binding molecules that facilitate the uptake of antigen into cells, antigen-binding molecules that can promote the reduction of antigen concentration in plasma, and can bind antigen multiple times It is an object of the present invention to provide an antigen-binding molecule, an antigen-binding molecule with improved pharmacokinetics, a pharmaceutical composition containing such an antigen-binding molecule, and a method for producing them. The inventors of the present invention have an antigen binding activity at a pH in early endosomes that is weaker than an antigen binding activity at a pH in plasma, and an antibody having a human FcRn binding activity at a pH in plasma is an antigen. Facilitates uptake of cells into the cell, such antibodies can increase the number of antigens that a single molecule of antibody can bind, and promote administration of such antibodies to reduce antigen in the plasma. It has been found that the use of such an antibody can improve the pharmacokinetics of the antibody. |