abstract |
The present invention relates to poly (ADP-ribose) polymerase (PARP) inhibitory groups and reactive oxygen species (ROS) scavenger groups, more specifically lipoic acid or cyclic nitroxide derivatives covalently linked directly or via a linker. Bifunctional compounds comprising and pharmaceutical compositions comprising them. The compounds and pharmaceutical compositions of the invention are useful for the prevention, treatment or management of diseases, disorders and conditions associated with elevated PARP activity or expression. |