| abstract |
The present invention relates to a novel picolinamide and pyrimidine-4-carboxamide compound, a process for producing the compound and a pharmaceutical composition comprising the compound, and selective inhibition of 11β-HSD1 enzyme of the compound The present invention relates to a pharmaceutical use to be used as an agent for preventing, regulating and treating a disease related to regulation of glucocorticoid by utilizing its activity. The picolinamide and pyrimidine-4-carboxamide compounds of the present invention are selective inhibitors of the human-derived 11β-HSD1 enzyme and are used to regulate glucocorticoids involving the 11β-HSD1 enzyme. Such diseases, for example, type 1 and type 2 diabetes, late diabetic complications, adult latent autoimmune diabetes (LADA), insulin resistance, obesity, impaired glucose tolerance (IGT), fasting hyperglycemia (IFG), abnormal It is useful as a prophylactic, modulating, and therapeutic agent for metabolic syndromes such as lipemia, arteriosclerosis, and hypertension. |