abstract |
Formula (I): R 1 is phenyl substituted with 0 to 3 substituents; R 1 , R 2 , R 3 , R 4 , R 5 and G are as defined herein) or a stereo thereof Isomers, salts, or prodrugs are provided. Also disclosed are the use of such compounds as selective agonists of the G protein coupled receptor S1P 1 and pharmaceutical compositions comprising such compounds. These compounds are useful for the treatment, prevention or delay of progression of various diseases or disorders in a wide therapeutic range, such as autoimmune and vascular diseases. |