| abstract |
The present invention provides a compound of formula 1: Wherein: (A) is heteroaryl or aryl; when present, each (A ′) is independently aryl, arylalkoxy, arylalkyl, heterocyclyl, aryloxy, halo, alkoxy, haloalkyl, cyclo Selected from alkyl, haloalkoxy and cyano, wherein each (A ′) is halo, haloalkyl, haloalkoxy, aryl, arylalkoxy, alkyl, alkoxy, amide, —CH 2 C (═O) NH 2 , hetero Substituted with 0, 1, 2, or 3 substituents independently selected from aryl, cyano, sulfonyl and sulfinyl; X is 0, 1, 2, or 3; (B) A cyclopropyl ring, wherein (A) and (Z) are covalently bonded to different carbon atoms of (B); ) Is -NH-; (L) is a single bond, -CH 2 -, - CH 2 CH 2 -, - CH 2 CH 2 CH 2 - and -CH 2 CH 2 CH 2 CH 2 - is selected from And (D) is an aliphatic carbocyclic group or benzocycloalkyl, wherein the aliphatic carbocyclic group or benzocycloalkyl is —NH 2 , —NH (C 1 -C 6 Alkyl), —N (C 1 -C 6 alkyl) (C 1 -C 6 alkyl), alkyl, halo, amide, cyano, alkoxy, haloalkyl and haloalkoxy independently selected from 0, 1, 2 or Having three substituents). The compounds of the present invention exhibit activity for inhibiting LSD1 which is useful in the treatment or prevention of diseases such as cancer. |