| abstract |
Black bear parathyroid hormone (PTH) and functional fragments thereof are provided. Furthermore, increase cAMP in osteogenic cells, decrease apoptosis in osteogenic cells, decrease the expression level ratio of Bax protein to Bcl-2 protein in osteogenic cells, bone matrix protein, transcriptional activation Increase the expression level of one or more factors or transcriptional regulators in osteogenic cells, increase bone mineral density, increase bone mass, decrease bone loss, or incidence of fracture Of black bear PTH and functional fragments are provided to reduce or reduce any combination of the foregoing, and antibodies against black bear parathyroid hormone (PTH) and functional fragments thereof are also provided. Provided. |