| abstract |
MEK inhibitor N- {3- [3-cyclopropyl-5- (2-fluoro-4-iodo-phenylamino) -6,8-dimethyl-2,4,7-trioxo-3,4,6,7 A novel combination comprising tetrahydro-2H-pyrido [4,3-d] pyrimidin-1-yl] phenyl} acetamide, or a pharmaceutically acceptable salt or solvate thereof, and an mTOR inhibitor, Pharmaceutical compositions comprising and methods of using such combinations and compositions in the treatment of conditions where inhibition of MEK and / or mTOR is beneficial, eg cancer. |