| abstract |
The present invention provides a therapeutic combination comprising: (a) a compound of formula (I) as described herein and (b) an alkylating agent or alkylation as described herein. Like agent, antimetabolite, topoisomerase I inhibitor, topoisomerase II inhibitor, growth factor or growth factor receptor inhibitor, anti-mitotic agent, proteasome inhibitor, anti-apoptotic protein inhibitor and cell surface protein One or more anti-neoplastic agents selected from the group consisting of antibodies to, wherein the active ingredient is in each case in its free form or a pharmaceutically acceptable salt or any hydrate Present in form. |