| abstract |
The subject of the present invention are compounds for modulating or controlling serine / threonine and tyrosine kinases, methods for their preparation, pharmaceutical compositions, use of compounds, methods and serine / threonine and tyrosine kinase modulators. The present invention relates to a novel small molecule compound having kinase inhibitory activity having excellent properties as a pharmaceutical, a method for producing the same, and a method for using the same. Specifically, the present invention exhibits excellent pharmacological action and is useful in the treatment of disease states, particularly cancers that depend on serine / threonine and tyrosine kinases such as, but not limited to, leukemia and solid tumors. Is a novel derivative of tetrahalogenated benzimidazole with serine / threonine and tyrosine kinase inhibitory properties selected from the group of PIM, HIPK, DYRK, CLK, CDK, FLT, PKG, Haspin, MER, TAO, MNK, TRK kinase About. |