| abstract |
The present invention provides a synthetic non-DNA base-containing polynucleotide sequence of 3 to 30 bases in length comprising one or more non-DNA in combination with a pharmaceutically acceptable vehicle, particularly one or more adjuvant vehicles and one or more antigens. And a base is a combination of nebulaline, hypoxanthine, or uracil, or nebulaline, hypoxanthine, and uracil base. The present invention relates to the use of these compositions in methods for inducing or modulating an immune response in vitro or in vivo, in particular for activating antigen presenting cells. |